Author/Editor		Pohar, Bojan; Horvat, Matija
Title		Influence of hemodynamic changes on neuroendocrine response in acute heart failure
Type		članek
Source		Int J Cardiol
Vol. and No.		Letnik 60
Publication year		1997
Volume		str. 263-71
Language		eng
Abstract		We studied 15 patients with acute deterioration of chronic left ventricular heart failure. We compared the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics on plasma concentration of epinephrine, norepinephrine, aldosterone and renin activity. Reduction of ventricular filling pressures with glyceryl with glyceryl trinitrate had no influence on plasma concentrations of epinephrine, norepineprhine, aldosterone and renin activity. After reduction of ventricular filling presures with diuretics palsma concentrations of epinephrine, norepinephrine and aldosterone decreased, while plasma renin activity did not change. We conclude that there is a difference in the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics, on neuroendocrine response in patients with acute deterioration of left ventricular heart failure. Thus some of the neuroendocrine effects of glyceryl trinitrate are likely to be different from those of diuretics, though that they both produce a reduction in left ventricular filling pressure.
Descriptors		HEART FAILURE, CONGESTIVE ALDOSTERONE NOREPINEPHRINE EPINEPHRINE VENTRICULAR PRESSURE RENIN ACUTE DISEASE HEART RATE NITROGLYCERIN RADIOIMMUNOASSAY VASODILATOR AGENTS VENTRICULAR DYSFUNCTION