Avtor/Urednik		Ebert, Eileen; Werle, Bernd; Julke, Britta; Kopitar-Jerala, Nataša; Kos, Janko; Lah, Tamara; Abrahamson, Magnus; Spiess, Eberhard; Ebert, Werner
Naslov		Expression of cysteine protease inhibitors stefin A, stefin B, and cystatin C in human lung tumor tissue
Tip		članek
Vir		Adv Exp Med Biol
Vol. in št.		Letnik 421
Leto izdaje		1997
Obseg		str. 259-65
Jezik		eng
Abstrakt		In human lung tumor tissue specimen (n=73) concentrations of stefins A and B were found to be increased 2.0-fold (p<0.01) and 1.3-fold (p<0.01), respectively, as compared to matched normal tissue. Stefin A and B concentrations were higher in primary tumors than in secondary tumors, i.e. metastases from other organs to the lung (<0.01: p<0.05, respectively). Cystatin C concentrations were rather low and did not differ beteen tumor and normal tissue. Both concentrationsof stefins did not correlate with TNM stages. Stefin F was higher in squamous cell carcinoma than in adenocarcinoma (p<0.01), while stefin B did not show such a differnce. At investigation of a relationship between survival probabiliry of patients with primary tumors it was found that increased stefin B concentrations and total cysteine-protease-inhibitory activities but not stefin A concentrations were positively correlated with survival probabiliry. It is concluded that stefins A and B are major contributors to the cysteine protease inhibitory activiry in primary lung tumors. Stefin B proved to be a prognostic factor, especially in squamous cell carcinoma.
Deskriptorji		LUNG NEOPLASMS CARCINOMA, SQUAMOUS CELL CYSTEINE PROTEINASE INHIBITORS CYSTATINS TUMOR MARKERS, BIOLOGICAL PROGNOSIS SURVIVAL ANALYSIS