Author/Editor		Poljak, Mario; Cerar, Anton; Seme, Katja
Title		Human papillomavirus infection in esophageal carcinomas: a study of 121 lesions using multiple broad-spectrum polymerase chain reactions and literature review
Type		članek
Source		Hum Pathol
Vol. and No.		Letnik 29, št. 3
Publication year		1998
Volume		str. 266-71
Language		eng
Abstract		To elucidate the putative role of human papillomavirus (HPV) infection in the etiology of esophageal cancer, 121 formalin-fixed, paraffin-embedded specimens originating from a non-high-incidence area for this carcinoma, from Slovenia, were screened for HPV infection using eight different polymerase chain reactions (PCR). Three different HPV consensus primer sets and four primer sets specific for HPV types 6, 16, and 18 failed to detect HPV DNA sequences in any of the tumor samples. Fragments of human beta-globin gene that served as internal controls were successfully amplified from 120 of 121 specimens. Our study confirms the opinion that most esophageal cancers originating from non-high-incidence geographic areas of this cancer are not associated with HPV infection. According to the studies reviewed, it is likely that HPV infection plays a much more significant role in esophageal carcinogenesis in those areas of the world with a high incidence of ESCC.
Descriptors		ESOPHAGEAL NEOPLASMS PAPILLOMAVIRUS, HUMAN PAPOVAVIRIDAE INFECTIONS CARCINOMA, SQUAMOUS CELL TUMOR VIRUS INFECTIONS AGED MIDDLE AGE DNA, NEOPLASM DNA, VIRAL POLYMERASE CHAIN REACTION RETROSPECTIVE STUDIES