Avtor/Urednik		Schmierer, K; Roericht, S; Niehaus, L; Meyer, BU
Naslov		Impaired transcallosal inhibition: an early indicator of central conduction deficits in multiple sclerosis
Tip		članek
Vir		In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi editore,
Leto izdaje		1998
Obseg		str. 119-23
Jezik		eng
Abstrakt		Magneto-electric stimuli applied focally to the primary motor cortex of one hemisphere using transcranial magnetic stimulation (TMS) have been found to suppress ongoing voluntary eletromyographic (EMG) activity in ipsilateral hand muscles. That this inhibition is mediated by callosal fibers and then by contralaterally projecting corticospinal connections could be shown in patients with capsular infarcts and transsection of the corpus callosum (CC). In patinets with multiple sclerosis (MS) white-matter lesions are concentrated in paraventricular regions, frequently involving the CC. In accordance with this, our study of 20 patients with early MS shows abnormalities of franscallosal motor cortex inhibition (TI) in 85% of the patients, whereas only 20% had abnormal cnetral motor latencies of motor responses in hand muscles. We conclude that the sensitivity of TMS in detecting deficits of conduction in fibres of the central nervous system in MS-patients can be increased by testing TI.
Deskriptorji		MULTIPLE SCLEROSIS NEUROPHYSIOLOGY CORPUS CALLOSUM MAGNETICS ELECTROMYOGRAPHY