Author/Editor		Zidar, Nina; Ferluga, Dušan
Title		Significance of nephron mass for the survival of renal graft and prognosis of renal disease
Type		članek
Source		In: Bren AF, Ferluga D, Olsen S, et al, editors. Proceedings of the International conference on transplantation with emphasis on kidney; 1998 Oct 8-9; Ljubljana, Slovenia. Ljubljana: Medical faculty, Institute of pathology,
Publication year		1998
Volume		str. 100-2
Language		eng
Abstract		On the basis of the hyperfiltration theory, much attention has been recently paid to the possible significance of the total nephron mass for the survival of renal graft and the progression of kidney diseases. There is mounting evidence that a reduced number of nephrons either congenital (as in persons with intrauterine growth retardation) or acquired (as in renal diseases, surgical excision, or transplantation of of one kidney) can contribute significantly to the progressive course of renal diseases and renal graft loss. Better understanding of factors influencing the variability in numbers of nephrons might contribute to the improvement of the survival of renal grafts. Furthermore, it might help to identify early in the course of renal diseases patients with an increassed risk of an unfavorable course.
Descriptors		KIDNEY TRANSPLANTATION GRAFT SURVIVAL NEPHRONS FETAL GROWTH RETARDATION AUTOPSY PROGNOSIS GLOMERULONEPHRITIS NEPHROTIC SYNDROME