| Avtor/Urednik | Malovrh, Tadej; Škoberne, Mojca; Kotnik, Vladimir | |
| Naslov | Celična imunost pri prepoznavi imunskih pomanjkljivosti in mikrobnih bolezni | |
| Prevedeni naslov | Importance of cellular immunity in recognition of immunodeficiencies and microbial infections | |
| Tip | članek | |
| Vir | Med Razgl | |
| Vol. in št. | Letnik 37, št. Suppl 5 | |
| Leto izdaje | 1998 | |
| Obseg | str. 109-14 | |
| Jezik | slo | |
| Abstrakt | Cellular immunity is our body's most important defence against intracellular parasites, tumor cells and foreign transplanted tissues. There are several laboratory tests which are used for determination of the number and function of immune cells involved in cellular immunity. Disorders in the number and function of distinct cells in relation to clinical signs can be evidence for immunodeficiency. Integrity of cellular immunity is often tested by the capability of T lymphocytes to respond to mitogens and antigens. In the lymphocyte blast transformation test we the mitogens to determine the status of the entire cellular immunity picture, while antigens used with the same method can be a diagnostic tool for some infectious diseases, e.g. Lyme borreliosis. | |
| Izvleček | Celična imunost je najpomembnejši del telesne obrambe pred znotrajceličnimi paraziti, tumorskimi celicami in tujimi presajenimi tkivi. Obstajajo različni laboratorijski testi, s katerimi lahko preverjamo število in funkcijske značilnosti celic, ki so poglavitne pri celični imunosti. Spremenjeno število in delovanje določenih celic v povezavi s kliničnimi znamenji je lahko dokaz za imunsko pomanjkljivost. neokrnjenost celične imunosti pogosto ugotavljamo z merjenjem zmožnosti limfocitov T, da se odzovejo na mitogene ali antigene. S testom blastnega preoblikovanja limfocitov merimo odzivnost limfocitov na mitogene, kar nam pokaže prizadetost celične imunosti v celoti, kadar pa v testu merimo odzivnost na določen antigen, lahko s testom blastnega preoblikovanja diagnosticiramo tudi določene infekcijske bolezni, npr. lymsko boreliozo. | |
| Deskriptorji | IMMUNOLOGIC DEFICIENCY SYNDROMES INFECTION IMMUNITY, CELLULAR BORRELIA BURGDORFERI LYMPHOCYTE TRANSFORMATION |