Avtor/Urednik		Kansky, A; Dolenc-Voljč, M; Bowden, PE; Belič, M
Naslov		Mycological examination in pachyonychia congenita
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 7, št. 3-4
Leto izdaje		1998
Obseg		str. 135-8
Jezik		eng
Abstrakt		Introduction. Pachyonychia congenita (PC) is a hereditary disorder of keratinization characterized by extremely thickened nails, follicular hyperkeratosis, insular palmoplantar keratoderma and thickened, whitish lingual and buccal mucosa sometimes involving also gingivae. It was established during the last few years that this disorder is due to mutations of keratin genes. The additional role of yeasts in the pathogenesis of PC was sometimes questioned, however no systemic study could be traced in the literature. Methods. mycologic investigations of nails and insular keratoses were carried out in eight Slovenian patients with PC-1: direct microscopy and cultivation on Sabouraud's dextrose agar. In all these patients the keratin mutations had been defined. Results. Candida species (Cand sp) were isolated from fingernails in two and Aspergillus sp in another patient. From toenails Cand sp was isolated in 2 and Rodotorula sp in another patient. From the keratinous material from the soles Trinchophyton mentagrophytes was isolated in two patients and Cand sp in another. Conclusion. Detection of Cand sp, Aspergillus sp or Rodotorula sp, spores in just a few patients is considered to be an accompanying phenomenon.
Deskriptorji		NAIL DISEASES MYCOSES CANDIDA ASPERGILLUS RHODOTORULA KERATOSIS TRICHOPHYTON