Author/Editor		Strojan, Primož
Title		Napovedni pomen katepsinov in njihovih endogenih inhibitorjev pri bolnikih s karcinomi glave in vratu
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1998
Volume		str. 112
Language		slo
Abstract		Backgroud: Cathepsins are ubiquitous lysosomal proteolytic enzymes. Cathepsins B, H and L belong to the class of cystecine or thiol proteinases, while cathepsin D belong to the class of aspartic protinases. Cystacin (stefins A and B, cystacin C) are endogenous, i. e. physiological inhibitors of cysteine proteinases, while an endogenous inhibitor of the aspartic protease of cathepsin D has not been found yet. Along with other cells protinases and inhibitors, cathepsins and cystatins are involved in proteolytic process which lead to invasion and dissemination of tumor cells. Therefore it is possible that their concentration in serum or tumor tissue cytosol correlates with the malignant potential of tumors and predicts the patient's survival. A correlation with patients' survival has been established particulary in the case of cathepsin D and breast cancer, where an increased cathepsin D expression is associated witha worse prognosis. In patients with other types of malignant tumors or in the case of other cathepsins is less clear. Aim: Our study was aimed to evaluate the prognostic value of cathepsins D, B, H and L, stefins A and B, and cystatin C in patients with carcinomas of the head and neck. (Abstract truncated at 2000 characters)
Descriptors		HEAD AND NECK NEOPLASMS CATHEPSINS CYSTATINS CATHEPSIN B CATHEPSIN D ENZYME-LINKED IMMUNOSORBENT ASSAY PROGNOSIS