Author/Editor		Šemrov, D; Miklavčič, D
Title		Calculation of the electrical parameters in electrochemotherapy of solid tumours in mice
Type		članek
Source		Comput Biol Med
Vol. and No.		Letnik 28
Publication year		1998
Volume		str. 439-448
Language		eng
Abstract		Electrochemotherapy is a novel approach in chemotherapeutic drug delivery into tumours. Short intense direct current electric pulses are applied to tumour tissue causing electropermeabilisation thus enabling entrance of chemotherapeutic drugs into cells which otherwise do not easily penetrate. A three dimensional anatomically based finite element model of the mouse with injected subcutaneous solid tumour was built. The main goal of the study was to evaluate the influence of the electrode orientation on the distribution of electric field in the tumour and surrounding tissue during electrochemotherapy. Two electrode configurations, previously examined in experimental study, were modelled. Electric field distributions were calculated for each configuration. The main conclusion of our study is that changing electrode orientation strongly influences the distribution of the electric field inside the tumour in the elecrochemotherapy of solid tumours in mice, which is in good agreement with the results of the experimental study. The efficacy of the electrochemotherapy depends on the magnitude of the electric field intensity inside tumour tissue.
Descriptors		NEOPLASMS, EXPERIMENTAL ELECTRIC STIMULATION THERAPY ANTINEOPLASTIC AGENTS MICE ELECTROPORATION MODELS, THEORETICAL ELECTROMAGNETIC FIELDS