Avtor/Urednik		Pfeifer, Marija; Verhovec, Renata; Žižek, Bogomir; Preželj, Janez; Poredoš, Pavel; Clayton, Richard N
Naslov		Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults
Tip		članek
Vir		J Clin Endocrinol Metab
Vol. in št.		Letnik 84, št. 2
Leto izdaje		1999
Obseg		str. 453-7
Jezik		eng
Abstrakt		Hypopituitary patients have increased mortality from vascular disease, and in these patients, early markers of atherosclerosis (increased carotid artery intima-media tickness (IMT) and reduced distensibility) are more prevalent. As GH replacement can reverse some risk factors of atherosclerosis, the present study examined the effect of GH treatment on morphological and functional changes in the carotid and brachial arteries of GH-deficient (GHD) adults. Eleven GHD hypopituitary men (24-49 yr old) were treated with recombinant human HG (0.018 U/kg BW-day) for 18 months. IMT of the common carotid artery (CCA) and the carotid bifurcation (CB), and flow-mediated endothelium-dependent dilation (EDD) of the brachial artery were measured by B mode ultrasound before and at 3, 6, 12, and 18 months of treatment, and values were compared with those in 12 age-matched control men. Serum concentrations of lipids, lipoprotein(a), insulin-like growth factor I (IGF-I), and IGF-I), IGF-binding protein-3 (IGFBP-3) were also measured. In GHD men before treatment the IMTs of the CCA (mean(SD), 0.67(0.05) mm) and CB (0.75(0.04) mm) were significantly greater (P < 0.001) than thos ein control men (0.52(0.07) and 0.65(0.07) mm, respectively). GH treatment normalized the IMT of the CCA by 6 months (0.53(0.04) mm) and that of the CB by 3 months (0.68(0.05) mm). The IMT of the carotid artery (CCA and CB) was negatively correlated with serum IGF-I (r=- 0.53; P < 0.0001). There was a significant improvement in flow-mediated EDD of the brachial artery at 3 months, which was sustained at 6 and 18 months of GH treatment (P < 0.05). GH treatment increased high density lipoprotein cholesterol at 3 and 6 months, but did not reduce total or low density lipoprotein cholesterol and was without effect on lipoprotein(a). (Abstract tuncated at 2000 characters)
Deskriptorji		ATHEROSCLEROSIS HYPOPITUITARISM SOMATOTROPIN VASCULAR DISEASES LIPIDS CAROTID ARTERIES ULTRASONOGRAPHY, DOPPLER BLOOD FLOW VELOCITY BRACHIAL ARTERY FEMORAL ARTERY