Author/Editor		Jackevič, JJ; Korž, AA; Kostrub, AA; Loskutov, AJ; Bilinski, BT; Jaremčuk, AJ; Pregelj, S
Title		Multicentrična klinična raziskava zdravljenja bolečine s Tramadolom v Ukrajini
Translated title		The Ukraininan multicentre clinical study on Tramadol in the management of painful conditions
Type		članek
Source		Krka Med Farm
Vol. and No.		Letnik 18, št. 29
Publication year		1997
Volume		str. 17-23
Language		slo
Abstract		Tramadol is a moderately potent analgesic, an opioid receptor agonist which possesses an additional effect resulting in a potentiation of the descending pain inhibition route in the spinal cord. The multicentre study on the efficacy and safety of Tramadol in the alleviation of acute postoperative pain in orthopedic surgery and traumatology included 74 patients. Additionally, Tramadol was administered to 30 cancer patients suffering from moderate or severe chronic pain. On 6 postoperative days, 90% of the patients reported that the alleviation of pain with Tramadol was excellent or good. The alleviation of chronic pain with Tramadol was also assessed as excellent or good by 80% of the cancer patients.
Summary		Tramadol je zmerno močan analgetik, agonist opioidnih receptorjev, ki okrepi tudi delovanje descendentne protibolečinske poti v hrbtenjači. V bulticentričnem preizkušanju učinkovitosti in varnosti Tramadola pri lajšanju akutne bolečine po ortopedskih ali travmatoloških operacijah je sodelovalo 74 bolnikov. Tramadol smo dajali tudi 30 bolnikom z rakom, ki so imeli zmerno hudo ali hudo kronično bolečino. 90% bolnikov je lajšanje bolečine s Tramadolom v 6 dneh po operaciji ocenilo kot odlično ali dobro. 80% bolnikov z rakom je lajšanje kronične bolečine s Tramadolom ocenilo kot odlično ali dobro.
Descriptors		PAIN TRAMADOL SPINAL CORD NEOPLASMS UKRAINE ANALGESICS