Author/Editor		Čižman, Milan; Kolbl, Jerneja
Title		Smernice razvoja protimikrobnega zdravljenja
Translated title		Trends of development of antimicrobial therapy
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 38, št. Suppl 2
Publication year		1999
Volume		str. 39-51
Language		slo
Abstract		Antibiotics have been used for many decades for treatment and prophylaxis in medical and veterinary practice and agriculture. Numerous bacteria became resistant to antibiotics due to their wide usage and frequently overuse and misuse. A rational and more appropriate usage of antimicrobial drugs should be based on deeper knowledge of bacterial resistance and the pharmacokinetic and pharmacodynamic characteristics of drugs. Trends in the development of antimicrobial therapy are moving towards shorter period of therapy, fewer daily doses of drugs, sequential therapy, outpatient treatment of serious infections, improved organisation in hospital antibiotic usage, education of physicians and patients and pharmacoeconomic involvement in medicine prescribing. By following these trends we could minimise the development of resistant bacteria, reduce the costs of therapy and treatment should become more acceptable for patients.
Summary		Antibiotike uporabljamo že več desetletij za zdravljenje in preprečevanje bolezni v medicini, veterini in poljedelstvu. Zaradi njihove široke, pogoste ter velikokrat nepravilne uporabe so nanje postale odporne številne bakterije. Racionalnejša in bolj usmerjena uporaba protimikrobnih zdravil temelji na boljšem poznavanju odpornosti bakterij in farmakokinetičnih ter farmakodinamičnih lastnosti zdravil. Razvoj protimikrobnega zdravljenja gre v smeri takega zdravljenje, manjšega števila odmerkov zdravila na dan, hitrejšega prehoda s parenteralnega zdravljenja na peroralno, ambulantnega zdravljenja težjih okužb, boljše organizacije uporabe antibiotikov v bolnišnicah, izobraževanja zdravnikov in bolnikov ter vključitve farmakoekonomike v predpisovanje zdravil. Vse to naj bi pripomoglo k zmanjšanju rezvoja odpornosti bakterij, bolj sprejemljivemu zdravljenju za bolnika in manjšim stroškom zdravljenja.
Descriptors		DRUG RESISTANCE, MICROBIAL ANTIBIOTICS COMMUNICABLE DISEASES DRUG UTILIZATION ECONOMICS, PHARMACEUTICAL PATIENT EDUCATION INFUSIONS, PARENTERAL