Avtor/Urednik		Marin, Jožica
Naslov		Povezanost med okužbo s herpesvirusi in nastankom neoplazem pri ljudeh
Prevedeni naslov		Herpesvirus infection and its relationship to the development of neoplasma in humans
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 68, št. 5
Leto izdaje		1999
Obseg		str. 309-12
Jezik		slo
Abstrakt		Background. Herpesviruses are very frequent pathogens in humans. Infections usually occur very early during lifetime. Primary infections which are symptomatic or asymptomatic are followed by latency, reactivations happen oftenly. COnclusions. Some of the herpesviruses are involved in the development of neoplasms, Epstein-Barr viruses being the most important among them. This virus is related to Burkitt's lymphoma, nasopharyngeal carcinoma and to the lymphoproliferative disorders of the immunocompromised persons. Epstein-Barr virus is also connected to one type of Hodgkin's disease and to some T-cell lymphoma. The tumor cells used to be genetically altered. The alterations might be provoked by the virus, while the tumor develops only by the contribution of numerous other factors.
Izvleček		Herpesvirusi so zelo pogosti povzročitelji okužb pri človeku. Z njimi se navadno srečamo že v prvih letih življenja. Po prvi okužbi, ki je simptomatična ali asimpromatična, lahko virusi mirujejo, občasno pa se reaktivirajo. Zaključki. Nekatere herpesviruse so vrsto let povezovali z neoplazmami. Najpogosteje omenjajo virus Epstein-Barr, ki sodeluje pri nastnaku Burkittovega limfoma, karcinoma nosu in žrela ter limfomov pri osebah s pomanjkljivim imunskim odzivom. Povezujejo ga tudi z določeno podvrsto Hodgkinove bolezni in z nastankom nekaterih T-celičnih limfomov. Neoplastične celice so genetično spremenjene. Spremembe lahko sproži virus, razvoj tumorja pa je odvisen še od številnih drugih dejavnikov.
Deskriptorji		NEOPLASMS HERPESVIRIDAE BURKITT'S LYMPHOMA HODGKIN'S DISEASE LYMPHOMA, B-CELL LYMPHOMA, T-CELL NOSE NEOPLASMS PHARYNGEAL NEOPLASMS