Author/Editor		Denišlič, Miro
Title		Zdravljenje Alzheimerjeve bolezni z zdravili, ki ne delujejo na acetilholinski sistem
Translated title		Non-cholinergic drugs in the treatmentof Alzheimer's disease
Type		članek
Source		In: Kogoj A, editor. Zdravljenje demenc: depresija in motnje spoznavnih sposobnost. Zbornik prispevkov 1. psihogeriatrično srečanje; 1998 nov 27-28; Kranjska Gora. Ljubljana: Združenje za pomoč pri demenci,
Publication year		1998
Volume		str. 20-7
Language		slo
Abstract		The heterogeneity of Alzheimer's disease and the still incomplete state of pathophysiological knowledge are serious challenges to the development of pharmacological therapies for dementia disorder. A major challenge for clinicians is how to delay or prevent progression of the disease. We have discussed the efficacy of estrogen replacement therapy by promotion of growth and survival of cholinergic neurons as well as by decrease of amyloid deposition. Furthermore - considering that inflammation is a part of the pathological pathway leading to Alzheimer's disease - the use of nonsteroidal anti-inflammatory drugs may play an important role in the improvement of memory and cognition. The free radicals are proposed to accelerate neuronal degeneration - antioxidants may block these toxic events. Also, N-methyl-D-aspartate antagonists, neurotrophic agents and nootropics can help to delay the illness. Finally, the drugs affecting the processing of beta-amyloid open new perspectives for the treatment.
Descriptors		ALZHEIMER'S DISEASE ESTROGENS ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL ANTIOXIDANTS AGED