Author/Editor		Wozel, G; Mrowietz, U
Title		The psoriasis plaque test on the stage
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 8, št. 2
Publication year		1999
Volume		str. 43-9
Language		eng
Abstract		To detect drugs with potential antipsoriatic activity a number of different methods are available (in vitro investigations, animal models, investigations in humans). Scientific interest has been focused on the development of clinical models because of the lack of a corresponding animal model for psoriasis. The psoriasis plaque test (PPT) as a classical within-patient trial is an important tool to study topical antipsoriatic drug activity in vivo. Many modifications in performing the PPT permit conclusions aiming at additional information, e.g. about the antipsoriatic drug activity per se as well as information on the mechanism of action, the dose-response relationship, the choice of vehicle, the application frequency or the local tolerability. An important prerequisite for correct performance of the PPT is the knowledge of toxicological and pharmacological data of the investigational compounds. Otherwise, the PPT is relatively simple, suitable and useful. The PPT can be seen as reference model for the evaluation of drugs with potential antipsoriatic activity. Nevertheless, the results of the PPT must be confirmed by controlled clinical trials.
Descriptors		PSORIASIS DRUG EVALUATION