Author/Editor		Korošec, Sara; Boc, Vinko
Title		Nosečnost in porod dvojčkov po postopku IVF-ET
Translated title		Twin pregnancy and birth after IVF-ET procedure
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 38, št. 1
Publication year		1999
Volume		str. 49-67
Language		slo
Abstract		A comparative study of singleton pregnancies after an IVF procedure revaled no significant differences in the course or outcome of pregnancy. On the other hand, multiple pregnancy itself is a risk factor for the course and oucome of pregnancy and birth. Since it is approximately twenty times more frequent in medically assisted than in natural conception and therefore constitutes one of the major problems of IVF pregnancy and birth. The aim of our research was to determine whether the course and obstetric outcome of twin IVF pregnancy differs from those in natural conception. This retrospective study included 731 women with twin pregnancies who gave birth to twins between April 1987 and May 1995. We studied 94 twin pregnancy mothers and 188 newborns conceived by an IVF procedure. The research project was divided into a cohort and control study. In the former, the study group was compared to the entire Ljubljana cohort of 637 mothers with twin pregnancy and 1274 newborns born after natural conception. In the control study, we compared the study group to 93 twin pregnancy mothers and 186 newborns born after natural conception. Women in the study group and control group were matched for age, parity and birth year. The course and complications of pregnancy, the course, complications and outcome of birth, and the characteristics of newborns were analysed. The incidence of severe complications of pregnancy, such as hypertension, eclampsy, polysymptomatic gestosis, gestation diabetes and threatened preterm labour, in the IVF group of mothers with twin pregnancy did not exceed that in the control group. (Abstract truncated at 2000 characters)
Summary		V primerjalni študiji enoplodnih nosečnosti po zunajtelesni IVF-ET niso našli večjih razlik v poteku in izidu nosečnosti. Mnogoplodna nosečnost pa predstavlja že sama po sebi dejavnik tveganja za potek in izid nosečnosti in poroda. Njena pogostnost je pri zunajtelesni oploditvi približno dvajsetkrat večja kot pri naravni zanositvi, zato predstavlja enega večjih problemov nosečnosti in poroda po postopku IVF-ET V naši raziskavi želimo ugotoviti, ali se potek in izid nosečnosti in poroda pri dvojčkih, spočetih po postopku IVF-ET razlikuje od tistih po spontani zanositvi. V retrospektivno raziskavo smo vključili 731 preiskovank z dvoplodnim izidom nosečnosti, ki so rodile dvojčke od aprila 1987 do maja 1995. Našo preiskovano skupino predstavlja 94 mater z dvoplodno nosečnostjo in 188 novorojenčkov, spočetih po postopku IVF-ET. Raziskavo smo razdelili na kohortno in kontrolirano študijo. Pri kohortni študiji smo primerjali preiskovano skupino s celotno Ijubljansko kohorto 637 mater z dvoplodno nosečnostjo in 1274 novorojenčkov po spontani zanositvi. Pri kontrolirani študiji pa smo primerjali preiskovano skupino s 93 materami z dvoplodno nosečnostjo in 186 novorojenčki po spontani zanositvi. Pri tej skupini so se matere ujemale s preiskovano skupino po starosti, pariteti in letu poroda. Primerjali smo potek in zaplete nosečnosti, potek, zaplete in izid poroda ter značilnosti novorojenčkov. V poteku nosečnosti nismo pri skupini mater IVF z dvoplodnim izidom nosečnosti ugotovili nič več hujših zapletov, kot so hipertenzija v nosečnosti, eklampsija, polisimptomatska gestoza, nosečnostna sladkorna bolezen in grozeči prezgodnji porod, kot pri kontrolni skupini. V primerjavi s kontrolno skupino smo ugotovili samo več krvavitev v prvem trimesečju in manj proteinurije. (Izvleček skrajšan pri 2000 znakih).
Descriptors		FERTILIZATION IN VITRO EMBRYO TRANSFER TWINS PREGNANCY, MULTIPLE OVULATION INDUCTION PREGNANCY INFANT, NEWBORN PREGNANCY COMPLICATIONS LABOR GESTATIONAL AGE BIRTH WEIGHT