Author/Editor		Fajdiga, Igor
Title		Prepoznava raka grla z lasersko izzvano fluorescenco
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1999
Volume		str. 102
Language		slo
Abstract		The early detection and accurate determination of the site and extent of a laryngeal cancer have fundamental influence on the improvement of treatment. Detection of different fluorescence characteristics in normal an malignant tissue without markers offers new diagnostic possibilities. This study was set with the aim to determine the role of fluorescence laryngoscopy (FL) in the detection of laryngeal cancer and risk epithelium (pre-cancer stage) by its comparison to standard laryngomicroscopy (LMS). Our hypothesis was that FL is more successful. Fluorescence imaging was performed with Lung Fluorescenee Endoscopy (LIFE) system developed at the British Columbia Cancer Agency in VancouveT which has considerably improved the detection of early lung cancer and pre-cancerous stages. After testing several optic instruments we have chosen rigid laryngeal telescope (A5281, Olympus, Tokyo, Japan) because of its better imaging qualities instead of the original fiber-optic bronchoscope. The fluorescence was induced by blue light (442 nm) and captured by an image-intensified cameras through the laryngeal telescope. After being processed by the system it was then displayed as fluorescence image of larynx on the video monitor in real time: normal tissues appeared green while malignant sites were reddish-brown. 111 patients were included in the study. In most of them laryngeal malignancy was suspected after mirror laryngoscopy. The examination started with LMS for initial clinical evaluations. Areas suspected for cancer were noted for subsequent biopsy. Fluorescence laryngoscopy was then performed with the LIFE system connected to the rigid telescope. (Abstract truncated at 2000 characters).
Descriptors		LARYNGEAL NEOPLASMS LARYNGOSCOPY FLUORESCENCE HYPEREMIA INFLAMMATION LEUKOPLAKIA EPINEPHRINE PAPILLOMA