Avtor/Urednik		Lovrečič, Mercedes; Canoniero, Stefania; Aglietti, Mirella; Maremmani, Icro
Naslov		Stabilizacijski omerki metadona in obstanek v obravnavi oseb, odvisnih od heroina, s pridruženo motnjo razpoloženja
Prevedeni naslov		Methadone stabilization dosages and retention in treatment in heroin addicts with axis psychiatric comorbidity for mood disorders
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 68, št. 10
Leto izdaje		1999
Obseg		str. 555-8
Jezik		slo
Abstrakt		Background. Heroin addicts with comorbid mood disorder have less favorable prognosis in present treatment programes. The aim of our study was to find out the differences between group of heroin addicts with comorbid mood disorder and group of heroin addicts without psychiatry comorbidity. Patients and methods. Opioid-dependent subjects with comorbid mood disorder and subject without comorbidity were included. They were followed up 990 days and doses of methadone and retention in treatment were recorded. The life table statistical method was used. Results. We studied 76 opioid-dependent subjects, 24 with cumorbid mood disorder. There were statisticaly significant diferences between these two groups regarding the methadone dose required for clinical stabilization. Patients with comorbid mood disorders required high eraverage stabilization dose during methadone maintenance treatment (135 mg/day) compared to subject without comorbidity (99 mg/day). During the study period there was no difference in retention in treatment between the two groups of patients. Conclusions. Heroin addicts with comorbid rnood disorder had better retention rate in metadone treatment programe whether the stabilization methadone dosage is adjusted.
Izvleček		Izhodišča. Osebe, odvisne od heroina, s pridruženo motnjo razpoloženja imajo v obstoječih programih obravnave slabšo prognozo. Med skupino odvisnih od heroina s pridruženo motnjo razpoloženja in skupino odvisnih brez pri- družene motnje smo želeli ugotoviti razlike med odmerki metadona, potrebnega za klinično stabilizacijo, in obstankom v programu. Bolniki in metode. Vključili smo odvisne od heroina s pridruženo motnjo razpoloženja in odvisne brez nje. Bolnike smo spremljali 990 dni in beležili odmerek metadona ter obstanek v obravnavi. Uporabili smo analizo preživetja. Rezultati.Raziskava je zajela 76 odvisnih od heroina, od katerih jih je 24 imelo pridruženo motnjo razpoloženja. Ostalih 52 odvisnih je bilo brez druge duševne motnje. Odvisni z motnjami razpoloženja so potrebovali višje stabilizacijske odmerke metadona v času obravnave (povprečno 135 mg metadona dnevno) v primerjavi z odvisnimi brez pridruženih motenj (povprečno 99 mg metadona dnevno). V opazovanem 990-dnevnem obdobju razlik v obstanku v programu med skupinama ni bilo. Zaključki. Odvisni od heroina s pridruženimi motnjami razpoloženja imajo večjo možnost, da obstanejo v opisanem metadonskemprogramu, če jim prilagodimo odmerek metadona.
Deskriptorji		HEROIN DEPENDENCE METHADONE AFFECTIVE DISORDERS, PSYCHOTIC TREATMENT OUTCOME DOSE-RESPONSE RELATIONSHIP, DRUG