Author/Editor		Putrino, I; Baccarini, P; Bračko, M; Foschini, MP; Collina, G
Title		Melanoma maligno con marcata reazione pseudoepiteliomatosa: descrizione di un caso
Translated title		Primary malignant melanoma with pseudoepitheliomatous reaction marker: a case report
Type		članek
Source		Pathologica
Vol. and No.		Letnik 90, št. 4
Publication year		1998
Volume		str. 397-402
Language		ita
Abstract		Pseudoepitheliomatous hyperplasia or pseudocarcinomatous hyperplasia (PEH) is characterized by a downward expansion of the epidermis, which can simulate a squamous cell carcinoma (SC). It is usually associated to chronic inflammatory conditions, but rarely it can hide a tumour. In the present paper a case of melanoma (M) associated with a prominent PEH is described. The patient is a 79-year old woman who presented a polypoid, ulcerated lesion of the left thigh. The lesion was entirely removed. The patient is free of disease 5-years after surgery. On histology, the malignant melanomatous proliferation was closely admixed to sheets of squamous cells. The possibility of SC was excluded as the squamous component did not show architectural disarray, prominent nucleoli and atypical mitoses. Siringomatous metaplasia was observed in the deeper portion of the lesion. On the basis of these findings the diagnosis of melanoma (M) associated to prominent PEH was considered the most likely.
Descriptors		MELANOMA AGED CARCINOMA CARCINOMA, SQUAMOUS CELL HYPERPLASIA SKIN NEOPLASMS SKIN ULCER