Avtor/Urednik | Malovrh, Petra; Sepčić, Kristina; Turk, Tom; Maček, Peter | |
Naslov | Characterization of hemolytic activity of 3-alkylpyridinium polymers from the marine sponge Reneira sarai | |
Tip | članek | |
Vir | COMP BIOCHEM PHYSIOL C | |
Vol. in št. | Letnik 124 | |
Leto izdaje | 1999 | |
Obseg | str. 221-6 | |
Jezik | eng | |
Abstrakt | Polymeric alkylpyridinium salts (poly-APS) isolated from the marine sponge Reniera sarai act as potent anticholinesterase agents; in addition they show moderate hemolytic and cytotoxic activities. The hemolytic activity of poly-APS is due to their detergent-like structure and behavior in aqueous solutions. In this work, the hemolytic activity of poly-APS is analyzed and compared to that of structurally-related monomeric cationic surfactants. The influence of different divalent cations and lipids on poly-APS induced hemolysis is discussed. The dimensions of lesions caused by poly-APS in erythrocyte membranes are determined by the use of osmotic protectants. Finally, the possible role of poly-APS in their natural environment is proposed. | |
Deskriptorji | PYRIDINIUM COMPOUNDS PORIFERA ERYTHROCYTES HEMOLYSIS SURFACE-ACTIVE AGENTS CATIONS |