Author/Editor		Dolenc-Grošelj, Leja; Meglič, Bernard; Popović, Mara
Title		Prikaz bolnika z dvema primarnima pljučnima karcinomoma in nevrološko simptomatiko: zasevki v možganih in paraneoplastičnim sindromom
Translated title		Report of a patient with two primary lung carcinoma and neurological manifestations: metastasis in the brain and paraneoplastic syndrome
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 69, št. 1
Publication year		2000
Volume		str. 25-9
Language		slo
Abstract		Background. Cancers of some organs often give metastasis to the brain. Metastasis represent 25% of all brain tumor lesions. Paraneoplastic syndromes affecting the nervous system are remote effects of cancer without direct effect of th etumor massor its metastasis. Paraneoplastic syndromes affecting the nervous system are rare, since they affect less than 1% patients with small-cell lung or ovarian cancers. Methods and result. A patient with two primary lung carcinomas (adenocarcinoma and small-cell carcinoma) and with double neurological manifestations is presented: brain metastases of lung adenocarcimoma and paraneoplastic brainstem encephalitis and polyneurophaty as the remote effect of the small-cell cancer, is presented. Paraneoplastic syndromes of the nervous system are discussed. Conclusions. Despite that praneoplastic syndromes affecting the nervous system are rare, the possibility of them should be considered when the aetiology of the neurological manifestations is not clear. It should be kept in mind that paraneoplastic syndromes often evolve when the primary tumor is not yet identified.
Summary		Izhodišča. Karcinomi nekateih organov pogosto zasevajo v možgane, saj kar četrtino vseh možganskih tumorskih poškodb predstavljajo zasevki. Paraneoplastični sindromi živčnega sistema se razvijejo zaradi oddaljenega delovanja tumorja in ne neposrednega učinka tumorske mase ali zasevka. Nevrološki paraneoplastični sindromi so redki. Pojavijo se v manj kot 1% bolnikov z drobnoceličnim karcinomom pljuč ali ovarijskim karcinomom. Metode in rezultati. Prikazan je primer bolnika z dvema primarnima pljučnima karcinomoma (adenocarcinomom in drobnoceličnim karcinomom pljuč) ter dvojno nevrološko simptomatiko: zasevki v možganih kot posledica adenocarcinoma in paraneoplastičnim encefalitisom možganskega debla ter polinevropatijo zaradi oddaljenega delovanja drobnoceličnega karcinoma pljuč. Opisani so paraneoplastični sindromi živčnega sistema. Zaključki. Čeprav so pareneoplastični sindromi s prizadetostjo živčnega sistema redki, moramo nanje pomisliti vedno, kadar pri bolniku nevrološke simptomatike ne znamo etiološko pojasniti, saj se pogosto pojavijo, ko primarni tumor še ni dokazljiv.
Descriptors		ADENOCARCINOMA, BRONCHIOLO-ALVEOLAR CARCINOMA, SMALL CELL LUNG NEOPLASMS AGED PARANEOPLASTIC SYNDROMES NEOPLASM METASTASIS BRAIN NEOPLASMS