Avtor/Urednik		Gorenjak, M
Naslov		Presejalni testi za celiakijo - naše izkušnje
Prevedeni naslov		Screening tests for coeliac disease - our experience
Tip		članek
Vir		Slov Pediatr
Vol. in št.		Letnik 7, št. Suppl 1
Leto izdaje		2000
Obseg		str. 72-4
Jezik		slo
Abstrakt		The assessment of serum antibodies is a significant factor in diagnosing coeliac disease. The oldest and most valued methods of determining antigliadin antibodies IgG and IgA were supplemented by investigations of antiendomysial antibudies IgA, in combination with antigliadin antibodies representing a very specific and sensitive combination of serologic tests. The inclusion of antigliadin, antireticulin and antiendomysial antibodies in the ESPGAN criteria has changed this type of diagnosis into a routine laboratory procedure. Antibodies against tissue transglutaminase, representing a veritable antigen structure of the endomysium, are still in development and their actual diagnostic value remains unelucidated. Despite the nonspeciticity of antigliadin antibodies IgG, their assessment is still justified by their excellent sensitivity.
Izvleček		Določanje serumskih protiteles predstavlja v diagnostiki celiakije pomemben dejavnik. Najstarejša in uveljavljena določanja antigliadinskih protiteles IgG in IgA so dopolnile preiskave antiendomizijskih protiteles IgA, ki predstavljajo v kombinaciji z antigliadinskimi protitelesi zelo specifično in občutljivo kombinacijo seroloških testov. Vključitev antigliadinskih, antiretikulinskih in antiendomizijskih protiteles v merila ESPGAN kriterije je tovrstno diagnostiko spremenilo v rutinsko dejavnost laboratorijev. Za protitelesa proti tkivni transglutaminazi, ki predstavlja pravo antigensko strukturo endomizija, šele spoznavamo diagnostični pomen. Kljub nespecifčnosti antigliadinskih protiteles IgG je njihovo določanje še vedno smiselno zaradi njihove občutljivosti.
Deskriptorji		CELIAC DISEASE MASS SCREENING IGG GLIADIN REAGENT KITS, DIAGNOSTIC CHILD IGA