Avtor/Urednik		Kozjek, Franc; Manček, Bronja
Naslov		Populacijska farmakokinetika
Prevedeni naslov		Population pharmacokinetics
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 49, št. 2
Leto izdaje		1998
Obseg		str. 153-66
Jezik		slo
Abstrakt		Since people respond differently to a particular drug, it is desirable to study the pharmacokinetics of drug in target population (e.g. patients). NONMEN (non linear mixed effect modelling) is most widely used computer program for analyses sparse data, given by such studies, which requires sophisticated methods. Population methods posses several advantages over traditional methods: approach is cost effective, it recognises variability, identifies factors of different origin that may influence the pharmacokinetic behaviour of drug, and evaluates quantitatively the unexplanined part of variability.
Izvleček		Ljudje se različno odzivamo na zdravilo, zato je zaželeno, da so farmakokinetični parametri proučeni v ciljnih populacijah (bolnikih). Za analizo podatkov, pridobljenih v takih študijah, so potrebne izpopolnjene metode, med katerimi je najbolj uporabljan računalniški program NONMEN (nelinearno modeliranje mešanih učinkov). Populacijske metode imajo številne prednosti pred tradicionalnimi: so cenejše, prepoznavajo variabilnost, identificirajo različne dejavnike, ki vplivajo na farmakinetično obnašanje zdravila in ovrednotijo neznani del variabilnosti.
Deskriptorji		PHARMACOKINETICS DRUG EVALUATION NONLINEAR DYNAMICS DATA INTERPRETATION, STATISTICAL