Author/Editor		Hojs, Radovan; Ekart, Robert; Dvoršak, Benjamin
Title		Ateroskleroza pri bolnikih s kronično ledvično odpovedjo tik pred začetkom hemodializnega zdravljenja
Translated title		Atherosclerosis in patients with chronic renal failure just before hemodialysis treatment
Type		članek
Source		In: Buturović-Ponikvar J, Bren AF, editors. Zbornik 2. slovenski nefrološki kongres z mednarodno udeležbo ob 30. letnici dialize in transplantacije ledvic v Sloveniji; 2000 sep 27-30; Brdo pri Kranju. Ljubljana: Klinični center, Klinični oddelek za nefrologijo,
Publication year		2000
Volume		str. 137-42
Language		slo
Abstract		Background. In dialysis patients the prevalence of coronary artery disease is appro imately 40 % and cardiovascular mortality is 10 to 20 times higher than in general population. The concept of accelerated atherogenesis would predict that the rate of ischaemic heart disease should progress with increasing duration on hemodialysis, but this is not seen in observational studies. Atherosclerosis in chronic renal patients before dialysis treatment has received less attention to date. Patients and methods. Using B-mode ultrasonography (ATL HDI 3000), we compared intima-media thickness (IMT) in the common carotid arteries and plaque occurrence in the common carotid arteries, in the area of bifurcation, and in internal carotid arteries (indicators of atherosclerosis) in 34 patients with chronic renal failure just before dialysis treatment with that in 28 control subjects without renal failure. We also investigated the relations of these variables to atherosclerotic risk factors in patients with renal failure. Results. We found no difference in age and sex between patients and control subjects. The IMT values (0,77 versus 0,61 mm; P<0,002) were significantly higher in patients and plaques occurrence (P<0,003) and number of plaques were significantly higher (P<0,006) in patients. In patients there was relationship (multiple stepwise regression analysis) only between IMT and age (P<0,0001), we found no relationship between IMT and atherosclerotic risk factors. Age and smoking were the only significant determinants for plaque occurrence (P<0,0001 and P<0,001) and number of plaques (P<0,001 and P<0,008). Conclusions. The results indicate that patients with chronic renal failure before starting hemodialysis showed advanced atherosclerosis in carotid arteries compared with control subjects without renal failure. Age was the only significant determinant for IMT and age and smoking for plaque occurrence and number of plaques.
Descriptors		ATHEROSCLEROSIS KIDNEY FAILURE, CHRONIC CAROTID ARTERIES CORONARY DISEASE