Author/Editor		Kocijančič, Borut; Ivanuša, Marijan
Title		Gastroezofagealna refluksna bolezen, zdravljenje in samozdravljenje
Translated title		Gastroesophageal reflux disease - treatment and self-treatment
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 51, št. 1
Publication year		2000
Volume		str. 87-93
Language		slo
Abstract		The number of patients afflicted with gastroesophageal reflux disease (GERD) is increasing. The most common and the most typical symptom of GERD is heartburn. The prevelance of heartburn is extremely high. Approximately one fourth of the patients referred for endoscopic examination due to dyspeptic symptoms have esophagitis. German statistics show that GERD affects 10% of the population, that 10% of these patients develop Barrett's esophagus and that 10% of the patients with this complication develop cancer of the esophagus. GERD may have a chronic course, therefore, long-term treatment is frequently required. As a rule, most patients with GERD begin self-treatment before they consult a physician. The majority of them use antacids. The physicians' decisions on the treatment approach are based either on the typical clinical picture of the disease or on the findings of the diagnostic tests. They may decide between prokinetics (mostly cisapride) and inhibitors of gastric secretion (proton pump inhibitors, H2-receptor inhibitors). These medicines may be used in combination.
Summary		POVZETEK: Gastroezofagealna refluksna bolezen (GERB) je vse pogostejša. Najpogostejši in najznačilnejši simptom GERB je zgaga. Prevalenca zgage je izjemno visoka. Približno četrtina bolnikov, ki opravijo endoskopsko preiskavo zaradi dispeptičnih težav, ima ezofagitis. Nemške statistike kažejo, da ima 10 % prebivalstva GERB, pri 10 % teh bolnikov se razvije Barrettov požiralnik in pri 10 % bolnikov s tem zapletom se v nekaj letih razvije rak požiralnika. Bolezen lahko ima kroničen potek, zato je pogosto potrebno dolgotrajno zdravljenje. Bolniki praviloma začnejo samozdravljenje še pred obiskom pri zdravniku. Najpogosteje uporabijo antacide. Zdravniki se lahko za zdravljenje odločijo na podlagi značilne klinične slike ali glede na izvide ustreznih preiskav. Odločajo se med prokinetiki (skoraj izključno cisaprid) in zaviralci želodčne sekrecije (blokatorji protonske črpalke, zaviralci receptorjev HZ). Zdravila iz teh dveh skupin lahko kombiniramo med seboj.
Descriptors		GASTROESOPHAGEAL REFLUX HEARTBURN BARRETT ESOPHAGUS ESOPHAGEAL NEOPLASMS ANTACIDS SELF ADMINISTRATION