Author/Editor		Meden, Anton; Jelen-Žmitek, Anita; Kaučič, Venčeslav; Kerč, Janez; Podobnik, Barbara; Žmitek, Janko
Title		Uporaba rentgenske praškovne difrakcije za določanje sledov kristaliničnega nifedipina v matriksu trdne farmacevtske oblike
Type		članek
Source		In: Glavič P, Brodnjak-Vončina D, editors. Zbornik referatov s posvetovanja Slovenski kemijski dnevi 2000: 1. in 2. del; 2000 sep 28-29; Maribor. Maribor: FKKT,
Publication year		2000
Volume		str. 113-8
Language		slo
Abstract		A quantitative method for determination of crystalline nifedipine in tablets with amorphous active compound was developed. Analysis of routinely collected powder diffraction patterns of all nine components, composing the tablets, led to a short collection range (9-13.5 deegre 2thetov) and long integration time (354 seconds) that enabled detection of crystalline nifedipine in tablets from 0.5 mass % on. The crystalline nifedipine was not found in neither fresh or aged tablets.
Descriptors		NIFEDIPINE TABLETS X-RAY DIFFRACTION DRUG INDUSTRY