Avtor/Urednik		Černe, Katarina; Drevenšek, Gorazd; Budihna, Metka V
Naslov		Lacidipine decrease the honeybee venom-induced vasoconstriction of the isolated porcine coronary artery
Tip		članek
Vir		Pflugers Arch
Vol. in št.		Letnik 440, št. 5 Suppl
Leto izdaje		2000
Obseg		str. R139-40
Jezik		eng
Abstrakt		The venom of the honeybee Apis mellifera induces cardiovascular dysfunction. As its effects on coronary arteries have not yet been described, we studied the effects of the whole honeybee venom (non-volatile part) in the isolated porcine left anterior descending coronary artery (LAD) and the influence of L-type Ca 2 channel blocker, lacidipine, upon the venom effects in LAD. The venom produced concentration dependent contractions (7 -70 micro g/ml) of the porcine LAD; maximal effect of the venom was approximately the same as the effect of 30 mM KCL Lacidipine concentration dependently (0.1-10 micro M) and significantly (P <= 0.05) decreased the venom-induced vasoconstriction. The results indicate the involvement of L-type Ca2+ channels in coronary contraction, induced by bee venom.
Deskriptorji		BEE VENOMS CORONARY VESSELS CORONARY VASOSPASM CALCIUM CHANNEL BLOCKERS SWINE