Avtor/Urednik		Kirschfink, Michael
Naslov		Immune escape mechanisms of pathogenic microorganisms
Prevedeni naslov		Načini, kako se patogeni mikroorganizmi izmaknejo gostiteljevi obrambi
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 39, št. Suppl 4
Leto izdaje		2000
Obseg		str. 47-52
Jezik		eng
Abstrakt		Microorganisms interact with the immune system in a large variety of ways. Through evolution they have developed various strategies to escape the host immune system. With increasing understanding of the biology of pathogenic microorganisms and the molecular basis of infectious disease, the constant battle between microbial survival strategies and host defence tactics as a principle of coevolution becomes obvious. Through multiple mechanisms pathogens are able to actively block almost any cellular or humoral immune response. These include antigenic variation, interference with antigen presentation, cytokine action, T cell response as well as resistance to phagocytosis and complement-mediated destruction. Studies with infectious microorganisms have provided stimulating new insights into the principal mechanisms relevant to immunology. This review will especially focus on strategies of how microorganisms avoid the deleterious attack of an activated complement system.
Izvleček		Z evolucijo so mikroorganizmi razvili več načinov, s katerimi se lahko izognejo gostiteljevi obrambi. Z vse večjim razumevanjem biologije patogenih mikroorganizmov in poteka infekcijskih bolezni na molekulski ravni postaja očitna z evolucijo pogojena soodvisnost za preživetje med mikrobi in njihovimi gostitelji. Mnogi povzročitelji nalezljivih bolezni so sposobni aktivno preprečiti praktično skoraj vsako dejavnost celičnega, pa tudi protitelesnega imunskega odziva in naravne odpornosti. Med te načine sodijo: antigensko spreminjanje, oviranje predstavitve antigenov, delovanje citokinov, T-celični odziv ter odpornost na fagocitozo in s komplementom pogojeno uničenje. Trenutne raziskave odkrivajo pomembne nove poglede na razvoj teh načinov. V našem prispevku smo se osredotočili na razlago načinov, s katerimi se mikroorganizmi obranijo pred delovanjem komplementnega sistema.
Deskriptorji		BACTERIAL INFECTIONS ESCAPE REACTION IMMUNE SYSTEM MOLECULAR MIMICRY COMPLEMENT