Avtor/Urednik		Dolinšek, Jernej
Naslov		Ugotavljanje celiakije pri ožjih družinskih članih bolnikov s celiakijo - diagnotična vrednost serumskih antigliadinskih in antiendomizijskih protiteles
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2000
Obseg		str. 69
Jezik		slo
Abstrakt		The features of coeliac disease are changing. The prevalence of the disease is constantly increasing, and atypical and asymptomatic forms of the disease are being diagnosed more often. All untreated coeliac disease patients are at the risk of developing serious late complications of the disease. The need for early detection of all patients is therefore obvious and serological markers have proven to be the most powerful tool. Coeliac disease is known to be more common in certain groups. These groups are: patients with insulin dependent diabetes mellitus, patients with Down's syndrome, patients with autoimmune thyroid disorders, patients with Sjoegren's syndrome, cystic fibrosis, epilepsy and ataxia, patients with low stature, IgA deficit etc. Family members of known coeliac disease patients certainly represent one of the most important groups. Prevalence of the disease among family members is estimated to be between 1% and 12%. In order to assess the prevalence of the disease among family members of our patients we screened 106 first-degreee relatives of 45 coeliac disease patients. We analysed antigliadin (AGA) and antiendomysium (EMA) antibodies in all family members. Small bowel biopsy was recommended to relatives with positive serology. Biopsy speciemens were histologicaly examined. The prevalence of the disease was calculated as the number of coeliac disease patients among 100 first-degree relatives. Altogether 16 relatives (15.04%) had an increased level of at least one serological marker of coeliac disease. 15 relatives (14.15%) had an increased level of antigliadin antibodies IgG and 5 relatives (4.72%) had an increased level of antiendomysium antibodies. Only 4 relatives (3.77%) had increased levels of both antigliadin and antiendomysium antibiodies. (Abstract truncated at 2000 characters).
Deskriptorji		CELIAC DISEASE FAMILY IGG IGA AUTOANTIBODIES INTESTINE, SMALL BIOPSY PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE