Author/Editor		Brecelj, Jelka; Kambič-Budkovič, Mojca; Pečarič-Meglič, Nuška; Zidar, Janez
Title		Diagnostične preiskave in diagnostična merila pri multiple sklerozi
Type		članek
Source		In: Dšuban G, Šilc T, Vodušek DB, et al, editors. Simpozij Ocenjevanje invalidnosti, telesne okvare in potrebe po pomoči in postrežbi drugega pri nevroloških bolnikih; 2000 dec 8-9; Ljubljana. Ljubljana: Zavod za pokojninsko in invalidsko zavarovanje Slovenije, Invalidska komisija 2. stopnje,
Publication year		2000
Volume		str. 101-8
Language		slo
Abstract		The implications of the diagnosis of multiple sclerosis are profound. The clinician must therefore be careful in making it and in determining its relative certainty. The diagnosis remains fundamentally clinical and requires the demonstration of at least two episodes of neurological disturbance implicating distinct sites in the nervous system. Clinical assessment may be supplemented by a number of laboratory examinations. Magnetic resonance imaging (MRI) is of great value. The images however depend on the relative amounts of water protons in different brain areas and do not reveal either normal or pathological myelin. The changes produced by disease may be characteristic but are not specific for the disease process. A central element in the power of MRI is its ability to demonstrate clinically silent lesions. The role of lumbar puncture remains of great value in the assessment of complex cases where the question is whether the disease is immunologically mediated. This is particularly valuable those patients with a late-on progressive syndrome. Detection of oligoclonal bands is then highly informative. Application of the evoked potentials to multiple sclerosis is important because they can in principle differentiate between the demyelinative and axonal lesions and detect clinically silent lesions. Different modalities (visual, somatosensory, auditory and motor) are in use. The use of the Poser Committee's criteria for the diagnosis of multiple sclerosis is suggested.
Descriptors		MULTIPLE SCLEROSIS MAGNETIC RESONANCE IMAGING CEREBROSPINAL FLUID PROTEINS CEREBROSPINAL FLUID EVOKED POTENTIALS, SOMATOSENSORY