Author/Editor		Fink, Martina; Cotman, Marko; Rozman, Damjana
Title		Sterol-dependent and cAMP-dependent regulation of lanosterol 14alpha-demethylase, an enzyme involved in cholesterol biosynthesis
Translated title		Od sterolov odvisno in of cAMP-odvisno uravnavanje izražanja lanosterolne 14alfa-demetilaze, gena, ki kodira encim vključen v biosintezo holesterola
Type		članek
Source		Acta Biol Slov
Vol. and No.		Letnik 43, št. 1-2
Publication year		2000
Volume		str. 63-6
Language		eng
Abstract		Sterol regulatory element binding proteins (SREBP) mediate CYP51 gene expression in somatic cells, while in germ cells CYP51 gene expression is mediated by the cAMP-regulatory element modulator CREMt. We propose that the dual CYP51 gene regulation leads either to cholesterol or to synthesis of CYP51 metabolites whic are important in reproduction of mammals.
Summary		Proteini, ki se vežejo na s steroli uravnavana zaporedja (srebp), uravnavajo izražanje gena CYP51 v telesnih celicah, v moških spolnih celicah pa izražanje gena CYP51 uravnava od cAMP-odvisni element modulator (CREMt). Predpostavljamo, da dvojno uravnavanje izražanje gena CYP51 povzroči bodisi biosintezo holesterola ali pa biosintezo CYP51 metabolitov, ki so pomembni v reprodukciji sesalcev.
Descriptors		CHOLESTEROL LANOSTEROL CYTOCHROME P-450 GENES, REGULATOR GENE EXPRESSION REGULATION CYCLIC AMP STEROLS