Avtor/Urednik		Topić, Elizabeta
Naslov		Novi funkcionalni, prognostički i dijagnostički testovi bolesti jetre
Prevedeni naslov		New functional, prognostics and diagnostic tests of liver diseases
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 49, št. Spec Issue
Leto izdaje		1998
Obseg		str. 381-97
Jezik		cro
Abstrakt		Liver in the one of organs with most numerous functions in the body, thus the diagnosis of liver diseases requires a complex approach. Diagnostic pathway begins with standard liver function tests, determination of total bilirubin, protein albumin, aminotransferases, ALP, (GT and, lately, prothrombin time which allow assessment of the crucial liver functions and are performed in a majority of medical biochemistry laboratories. Further diagnosis of liver diseases includes recent diagnostic tests that have been developed in response to the understanding of the etiologic basis and pathobiochemical processes of the disease, and intended for the diagnosis of liver residual function and liver circulation as well as for the study of individual liver functions or integrity. Metabolic defects associated with liver disease, such as al-antitrypsin deficiency, hemocromatosis or Wilson's disease, can presently be detected at the biochemical level or by the methods of molecular biology. Viral hepatitis induced by A, B, C, D, E, or other non-A, B, C, D, E, hepatotropic viruses is the most common cause of acute hepatitis. Accurate identification of the cause and therapeutic success monitoring have been made possible using tests for the determination of the specific virus antigens and antibodies and PCR techniques for identification of virus particle RNA or DNA. The presence of antomitochondrial antibodies along with ALP and IgM increase is a characteristic feature found in 90% of patients with autoimmune lver diseases. Drug-induced hepatotoxicity can be diagnosed on the basis of clinical and laboratory parameters, whereas determination of genetic polymorphism (using the methods of molecular biology) of the enzymes involved in drug metabolism enables identification of the drug poor metabolising phenotype, thus allowing the toxic sequel to be diminished or even prevented.
Deskriptorji		LIVER DISEASES LIVER FUNCTION TESTS GLUTATHIONE TRANSFERASES CHOLESTASIS LIVER CIRRHOSIS LIVER TRANSPLANTATION LIVER NEOPLASMS LIVER DISEASES, ALCOHOLIC HEPATITIS, VIRAL, HUMAN HEPATITIS, TOXIC