Author/Editor		Milisav, Irina
Title		Mitohondrijske bolezni
Translated title		Mitohondrial diseases
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 70, št. 4
Publication year		2001
Volume		str. 227-31
Language		slo
Abstract		Background. Recent discoveries that mitochondria are involved in various diseases, ageing processes and have a central role in triggering and executing cell death have attracted the interest for these cellular organelles. Conclusions. Mitochondrial diseases arise as a consequence of lower energy production and are often the result of singlenucleotide errors, which lead to defects only later in life. The characteristic features are varied simptoms and complex inheritance patterns, since the diseases aries as a consequence of mutations in the mitochondrial or nuclear genes. Mitochondrial disorders are often expressed as neurodegenerative diseases, myopaties or endocrine system dysfunctions as well as in the processes of ageing.
Summary		Izhodišča. V zadnjem času se je povečalo zanimanje za delovanje mitohondrijev zaradi dokazane vpletenosti teh organelov pri različnih boleznih, procesih staranja in zaradi njihove centralne vloge pri določanju in izvedbi celične smrti. Zaključki. Mitohondrijske bolezni so posledica majhnih, pogosto maloštevilnih okvar, ki se z leti vse bolj izrazijo. Posledica okvar je zmanjšana tvorba energije, na kar so organi v različno občutljivi. Značilna je raznolikost simptomov in kompleksno delovanjje, saj so okvare posledica mutacij jedrnih ali mitohondrijskih genov. Tako se mitohondrijske okvare najpogosteje kažejo kot nevrodegenerativne bolezni in staranje.
Descriptors		MITOCHONDRIA DNA, MITOCHONDRIAL GENETIC SCREENING CELL DEATH AGING