Author/Editor		Možina, Hugon
Title		Patofiziološka dogajanja pri srčnem popuščanju
Translated title		Patophsysiology of heart failure - the basics
Type		članek
Source		Zdrav Vars
Vol. and No.		Letnik 40, št. 3-6
Publication year		2001
Volume		str. 129-32
Language		slo
Abstract		Heart failure is pathophysiological state in which the heart is unable to provide blood at a rate necessary to create oxygen transport for metabolizing tissues needs or can do so only from an elevated filling pressure. In the presence of a primary disturbance in myocardial contractility or an excessive hemodynamic burden, the heart depends on number of adaptive mechanisms for maintenance of its performance. Most important among these are Frank-Starling mechanism in which an increased preload (stretching of myocardium) sustains cardiac performance Myocardial hypertrophy Activation of neurohumoral systems Redistribution of left ventricular output. In the presenting article some diagrams are proposed that help to understand hemodynamic changes in heart failure, hemodynamic effect of adaptive mechanisms and therapeutic measures.
Summary		Srčno popuščanje je stanje, ko srce zaradi motenega delovanja ne more ustvariti zadostnega minutnega volumna krvi in tako ne more zagotoviti zadostnega prenosa kisika za presnovne potrebe telesa, ali pa to zmore samo z zvišanjem polnilnega tlaka srca. Prilagoditve na popuščanje srca Frank-Starlingov mehanizem. Pri zvišanju polnilnega tlaka srca in posledičnem večjem raztegu prekata v diastoli so opazili (izolirano srce brez neurohumoralnih vplivov) povečano moč krčenja in s tem večji utripni volumen srca. Hipertrofija srčne mišice. Nevrohumoralne prilagoditve. Prerazporeditev pretoka krvi. V prispevku so za razlago uporabljeni grafični prikazi, ki omogočajo lažje razumevanje hemodinamskih, sprememb pri srčnem popuščanju, odzivu telesa na srčno popuščanje in zdravljenju.
Descriptors		HEART FAILURE, CONGESTIVE