Avtor/Urednik		Radobuljac, Maja; Rogelj, Klemen
Naslov		Kognitivne motnje in depresivnost pri bolnikih s tortikolisom
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2000
Obseg		str. 58
Jezik		slo
Abstrakt		Background: Torticollis is a focal dystonia of the neck muscles, believed to reflect a disorder of the basal ganglia. It is successfully treated with botulinum toxin, but its aetiology and mechanism remain elusive. Recently five separate anatomical loops have been shown to connect basal ganglia to the frontal cortex: two motor, two cognitive and one limbic. Consequently besides motor disorder (dystonia) patients with torticollis could also have mood and cognitive impairment. Objectives: Our aim was to find out whether in patients with torticollis there is also an impairment of mood (depression), cognition and selective attention; and whether a successful symptomatic treatment with botulinum toxin alleviates these non-motor symptoms as well. Methods: In seven patients with torticollis we used questionnaires on body-concept and on ways of coping with the disease for assessment of mood (depression). Using event related potentials (the auditory oddball task and the auditory selective attention task) and reaction times we assessed cognition and attention. They were tested twice: before the treatment with botulinum and two months afterwards. Patients were compared to six age-matched healthy volunteers. Results: Our results show that patients with torticollis have negative body-concept, which improves after the treatment with botulinum toxin. There is no impairment of auditory selective attention. Auditory oddball potentials are of shorter latencies in patients, but their reaction times are longer. Conclusions: Depression in patients with torticollis seems to be largely reactive. Shorter latencies of the event related potentials might reflect an enhanced excitability of the cognition-related structures. The mechanism of the enhanced excitability has previously been shown with other methods for the motor and somatosensory systems, but ours is the first study that postulates the same mechanism also for the cognitive system. (Abstract truncated at 2000 characters).
Deskriptorji		TORTICOLLIS BOTULINUM TOXINS DEPRESSIVE DISORDER COGNITION DISORDERS NEUROPSYCHOLOGICAL TESTS EVENT-RELATED POTENTIALS, P300