Avtor/Urednik | Gobec, S; Urleb, S; Simčič, S; Wraber, B | |
Naslov | Synthesis and modulation of cytokine production by two new adamantane substituted acyclic desmuramyldipeptide analogs | |
Tip | članek | |
Vir | Pharmazie | |
Vol. in št. | Letnik 56, št. 7 | |
Leto izdaje | 2001 | |
Obseg | str. 523-6 | |
Jezik | eng | |
Abstrakt | Two new adamantyl-desmuramyldipeptides LK 415 and LK 517 with 1-adamantylcarboxamido moiety as a replacement for muramyldipeptide's N-acetylglucosamine grafment were synthetized. Their efficacy to modulate the production of cytokines was measured in vitro in ionomycin and phorbol-12-myristate-13-acetate (PMA) activated cultures of human peripheral blood mononuclear cells (PBMC), co-incubated with the substances tested. The results were compared with the activity of muramyldipeptide (MDP). All three substances are strong up-regulators of IL-12 synthesis and hence of the IFNgamma synthesis as well. While MDP and LK 415 are relatively inffective in modulation of IL-2, IL-4 and IL-10 production in vitro, the synthesis of all three cytokines is considerably up-regulated when peripheral blood mononuclear cells are co-incubated with LK 517.It seems likely that the introduction of the diethyl phosphonate moiety into LK 617 is of great importance for the augmented T-cell cytokine production. | |
Deskriptorji | ACETYLMURAMYL-ALANYL-ISOGLUTAMINE CYTOKINES MONOCYTES IONOMYCIN TETRADECANOYLPHORBOL ACETATE INTERLEUKIN-12 INTERLEUKIN-2 INTERLEUKIN-4 INTERLEUKIN-10 TUMOR NECROSIS FACTOR INTERFERON TYPE II |