Avtor/Urednik		Mlinarič-Raščan, Irena
Naslov		Focal adhesion kinase modulates B cell receptor-transduced apoptosis in WEHI 231 cells
Tip		članek
Vir		Pflugers Arch
Vol. in št.		Letnik 442, št. 6 Suppl 1
Leto izdaje		2001
Obseg		str. R157-8
Jezik		eng
Abstrakt		B cell receptor (BCR) cross-linking induces tyrosine phosphorylation and activation of focal adhesion kinase (FAK), suggesting the role of this molecule in BCR transduced signaling. The nature of FAK function in BCR induced apoptosis of VVEFII 231 lymphoblastoid cells was studied by overexpressing a C-terminal non-catalytic domain of FAK, termed focal adhesion targeted (FAT) domain. Clones overexpressing FAT protein exhibited a modified ability" of induction of programmed cell death at "low concentration threshold of anti-IgM antibodies; suggesxing that FAK may play a role in modulating IgM-induced apoptotic signaling.
Deskriptorji		APOPTOSIS LYMPHOMA, B-CELL PLASMIDS TRANSFECTION TUMOR CELLS, CULTURED IGM