Avtor/Urednik		Svetina, Saša; Žekš, Boštjan
Naslov		Membrane active compounds that affect the shape of cells and cellular organelles
Tip		članek
Vir		Cell Mol Biol Lett
Vol. in št.		Letnik 6, št. 2A
Leto izdaje		2001
Obseg		str. 305-11
Jezik		eng
Abstrakt		Amphiphilic membrane active compounds are considered that affect the shapes of cells and cellular organelles by intercalation into the phospholipid part of their membranes. It is taken into consideration that amphiphile-membrane interaction modifies membrane mechanical properties. The relationship between membrane mechanical properties and vesicle shapes and the concept of the bilayer couple model are shortly reviewed. Then it is put forward that the strength of the amphiphile-membrane interaction may depend on the lateral packing of phospholipid molecules. It is shown that in such a case the amphiphile molecules bind to the membrane in a cooperative manner. Moreover, the amphiphile binding makes the ratio between the nonlocal and local membrane bending constants to be effectively larger and thus widens the range of possible stable vesicle and cellular shapes.
Deskriptorji		MEMBRANES, ARTIFICIAL LIPID BILAYERS PHOSPHOLIPIDS CELL SIZE ORGANELLES ELASTICITY MODELS, THEORETICAL