Avtor/Urednik		Gurfinkel, Enriqe P
Naslov		Infection and atherosclerosis
Tip		članek
Vir		In: Štiblar-Martinčič D, Petrovič D, editors. Cardiovascular diseases. Proceedings of the 32nd memorial meeting devoted to professor Janez Plečnik, International symposium in memory of professor Rene Favaloro; 2001 Dec 6-8; Ljubljana. Ljubljana: Medical faculty,
Leto izdaje		2001
Obseg		str. 259-65
Jezik		eng
Abstrakt		At the turn of the century, infection was the leading cause of death in the world. Advances in sanitation and the introduction of antibiotics dramatically decreased the death toll of pneumonia, tuberculosis, and diarrheal diseases and heralded what was then considered the beginning of the end of the war against infection. As life expectancy lengthened, medical research turned away from infection and concentrated on the study of pathophysiology to battle the new scourges of the modern world- atherosclerosis and cancer. Research in the second half of this century led to the discoveries of hormonal, receptor, and most recently, genetic origins of disease. Just as we began to feel medicine was approaching the final frontier in the origin of disease two of the most prevalent diseases, asthma and peptic ulcers, were unexpectedly discovered to have important infectious components. To further question our understanding of common diseases, a recent randomized trial of antibiotics in patients with coronary artery disease demonstrated a significant improvement in those treated with a macrolide antibiotic. Remarkably, atherosclerosis, the most deadly disease of the end of the 20ž" century may indeed have an important infectious component that has been ignored for decades. Battling infection and the immune reactions in the 21st century will challenge all physicians, even cardiologists.
Deskriptorji		ATHEROSCLEROSIS ENDOTHELIUM, VASCULAR MACROPHAGES LYMPHOCYTES INFECTION CHLAMYDIA PNEUMONIAE CHLAMYDIA TRACHOMATIS