Avtor/Urednik		Kirbiš, Janez; Keše, Darja; Petrovič, Danijel
Naslov		Direct and serological evidence for an association between Chlamydia pneumoniae and acute coronary syndrome
Tip		članek
Vir		In: Štiblar-Martinčič D, Petrovič D, editors. Cardiovascular diseases. Proceedings of the 32nd memorial meeting devoted to professor Janez Plečnik, International symposium in memory of professor Rene Favaloro; 2001 Dec 6-8; Ljubljana. Ljubljana: Medical faculty,
Leto izdaje		2001
Obseg		str. 289-92
Jezik		eng
Abstrakt		The role of infectious agents in the pathogenesis of atherosclerosis has long been suggested. The aim of the study is to find an association between the infection with Chlamydia pneumoniae and acute coronary syndrome (ACS). The study population included 33 subjects withACS. In the control group there were healthy subjects without clinical evidence of coronary artery disease. In all (patients, control group) serum IgG, IgM and IgA antibodies to Chlamydia pneumoniae were determined, and sera were designated as positive (titer P:32) or negative (titer < 1:32). In patients with ACS the antigen of Chlamydia pneumoniae in the wall aorta near the right coronary ostia was determined with direct immunofluorescence and polymerase chain reaction. In patients with ACS we found IgG titres I:32 in 78.3 % and in healty 41-62 years old control subjects in 79 %. Based on serological data, in 15 patients with ACS (45.5 %) acute infection or exacerbation of infection with Chlamydia pneumoniae, in 12 (36.4 %) chronic infection with Chlamydia pneumoniae and in 6 (18.2 %) no evidence of Chlamydia pneumoniae was demonstrated. In 8 patients with ACS with acute infection or exacerbation of infection with Chlamydia pneumoniae (53.3 %) acute infection or exacerbation of infection with Chlamydia pneumoniae the bacteria Chlamydia pneumoniae has been demonstrated in the wall of aorta with the PCR method, whereas bacteria Chlamydia pneumoniae has been demonstrated only in 3 patients with ACS with chronic infection with Chlamydia pneumoniae (3 of 12=25 %) and in 2 patients with ACS with no serologic signs of infection (2 of 6=33.3 %). In conclusion, chronic infection with Chlamydia pneumoniae is common in subjects with ACS and in healthy control. Secondly, direct demonstration of Chlamydia pneumoniae is more common in patients with positive titres against Chlamydia pneumoniae compared to those patients with acute coronary syndrome with no serological signs of infection with Chlamydia pneumoniae.
Deskriptorji		CORONARY DISEASE CHLAMYDIA PNEUMONIAE CHLAMYDIA INFECTIONS IGG IGM IGA POLYMERASE CHAIN REACTION