Author/Editor		Bohanec, Simona; Kremžar, Ljuba
Title		Študij večkomponentnih mešanic s pomočjo modeliranja
Type		članek
Source		In: Glavič P, Brodnjak-Vončina D, editors. Zbornik referatov s posvetovanja Slovenski kemijski dnevi 1998; 1998 sep 17-18; Maribor. Maribor: FKTT,
Publication year		1998
Volume		str. 118-23
Language		slo
Abstract		The selection of the optimal composition of extended release tablets is described. The most important parameter for the quality of extended release tablets is the disolution profile that can be adjusted by ingredients - components of tablets. On the basis of preliminary experiments five key components were selected. Forthermore, fifteen experiments were carried out to adjust the ratio of components giving the tablets with specified disolution profile. The disolution profile for different wmpositions of tablets is predicted by the linear regresion models. The effects of particle size and the distribution of particles of the active substance on the disolution profile was also determined, but it is small in comparison with the effects of selected components.
Descriptors		DRUG COMPOUNDING TABLETS DRUG DELIVERY SYSTEMS CHEMISTRY, PHARMACEUTICAL