Author/Editor		Pikelj, Franjo; Trampuž, Andrej
Title		Diagnostika in zdravljenje okužb umetnih materialov
Translated title		Diagnosis and treatment of infections of foreign body materials
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 41, št. Suppl 2
Publication year		2002
Volume		str. 159-66
Language		slo
Abstract		Modern medicine has developed many artificial devices that substitute for the functions of damaged tissues or organs. However, all of these man-made materials represent foreign bodies in the human body; they trigger a host response, and are especially subject to infections. There are several factors that influence the development and course of infections. The most important and characteristic of these include: extracellular matrix (biofilm), which is formed on the surface of man-made materials; impaired phagocytic-bactericidal granulocyte capacity adjacent to the implant; and a great many agents with a low metabolic activity that are dependent on biofilm components, which reduce the effectiveness of antibiotics, especially those that inhibit bacterial cell wall synthesis. This paper presents the general principles of diagnosis and treatment of infections of artificial cardiac valves, neurosurgical bridgings, and urinary and dialysis catheters.
Summary		Moderna medicina je razvila številne umetne pripomočke, ki nadomeščajo delovanje okvarjenih tkiv ali organov. Vsi umetni materiali pa predstavljajo tujke v telesu, ki sprožijo gostiteljev odziv in so še posebej podvrženi okužbam. Pri nastanku in poteku okužb umetnih materialov sodeluje več dejavnikov. Med pomembnejšimi in značilnimi so: zunaj celični matriks (biofilm), ki se tvori na površini umetnih materialov; okvarjena fagocitno-baktericidna sposobnost granulocitov ob vsadku in veliko število presnovno malo aktivnih povzročiteljev, vezanih na sestavine biofilma, kar zmanjšuje učinkovitost antibiotikov, predvsem tistih, ki zavirajo sintezo bakterijske celične stene. V prispevku so predstavljeni splošni principi diagnosticiranja in zdravljenja okužb umetnih srčnih zaklopk, nevrokirurških spojev, urinskih ter dializnih katetrov.
Descriptors		PROSTHESIS-RELATED INFECTIONS HEART VALVE PROSTHESIS URINARY CATHETERIZATION EQUIPMENT CONTAMINATION IMPLANTS, ARTIFICIAL CEREBROSPINAL FLUID SHUNTS HEMODIALYSIS PERITONEAL DIALYSIS BACTERIAL INFECTIONS