Avtor/Urednik		Pirnat, E; Fidler, V; Zaletel, K; Gaberšček, S; Hojker, S
Naslov		Early change of thyroid hormone concentration after 131I treatment in patients with solitary toxic adenoma
Tip		članek
Vir		Nuklearmedizin
Vol. in št.		Letnik 41, št. 4
Leto izdaje		2002
Obseg		str. 178-83
Jezik		eng
Abstrakt		Aim: In spite of extensive use of 131I for treatment of hyperthyroidism, the results of early outcome are variable. In our prospective clinical study we tested whether 131I induced necrosis causing clinical aggravation of hyperthyroidism and increasing the free thyroid hormone concentration in the serum of patients with solitary toxic adenoma not pretreated with antithyroid drugs. Patients and methods: 30 consecutive patients were treated with 925 MBq 131I. Serum concentration of thyrotropin (TSH), free thyroxine (fT4), free triiodothyronine (fT3), thyroglobulin (Tg), and interleukin-6 (IL-6) were measured before and after application of 131I. Results: After application of 131I no clinical worsening was observed. FT4 and fT3 concentration did not change significantly within the first five days, whereas both of them significantly decreased after 12 days (p < 0.0001). Slight and clinically irrelevant increase in the level of the two thyroid hormones was observed in 9 patients. Furthermore, we observed a prolonged increase in Tg concentration and a transient increase in IL-6 concentration. Conclusion: Neither evidence of any clinical aggravation of hyperthyroidism nor any significant increase in thyroid hormone concentration by 131I induced necrosis of thyroid cells was found. Therefore, the application of 131I may be considered as a safe and effective treatment for patients with hyperthyroidism due to toxic adenoma.
Deskriptorji		IODINE RADIOISOTOPES THYROID HORMONES THYROID NEOPLASMS ADENOMA THYROTROPIN THYROXINE TRIIODOTHYRONINE THYROGLOBULIN INTERLEUKIN-6