Author/Editor		Ihan, A
Title		Izražanje in lastnosti receptorjev za IL-2 na celicah NK
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1990
Volume		str. 63
Language		slo
Abstract		INterferon gamma (IFN), interleukin-2 (IL-2) and tumor necrosis factors alpha (TNF) stimulate NK like lytic activity of peripheral blood lymphocytes in vitro against K562 cells. We investigated the effect of IFN, Il-2 and TNF on NK lytic activity of highly (more than 90 percent) purified population of NK cells. We founded, that only IL-2 considerably increases their activity. The affinity studies of IL-2 receptors on the same cells revealed, that IL-2 stimulated NK cells express increased number og high affinity IL-2 receptors, while TNF even decreases their expression. Though the TNF treatment eliminates detectable high affinity IL-2 receptor amount, the function of NK cells remains unaffected. These findings propose that mechanism of NK cells stimulation depends on cytokine nature.
Descriptors		KILLER CELLS, NATURAL INTERLEUKIN-2 RECEPTORS, INTERLEUKIN-2 INTERFERON TYPE II TUMOR NECROSIS FACTOR KILLER CELLS, LYMPHOKINE-ACTIVATED RADIOLIGAND ASSAY IODINE RADIOISOTOPES