Avtor/Urednik		Acuna, AA; Gabrijelčič, Jasmina; Uribe, EM; Rabinovich, R; Roca, J; Barbera, JA; Chung, KF; Rodriguez-Roisin, R
Naslov		Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma
Tip		članek
Vir		Eur Respir J
Vol. in št.		Letnik 19, št. 5
Leto izdaje		2002
Obseg		str. 872-8
Jezik		eng
Abstrakt		Inhaled glucocorticosteroids may reduce airway mucosal oedema in acute asthma. Inhaled platelet-activating factor (PAF) provokes pulmonary gas exchange disturbances, similar to those shown in severe asthma, which may be due to increased airway plasma leakage. This randomized, double-blind, placebo-controlled, crossover study investigated the effects of high doses of inhaled fluticasone propionate (FP) in 12 patients with mild asthma before and after PAF inhalation. Patients were studied before and 12 h after inhaling FP (6 mg) or placebo (P), and then at 5, 15 and 45 min after PAF challenge. Compared with vehicle, FP inhaled before PAF improved forced expiratory volume in one second and respiratory system resistance (Rrs), increased peripheral blood neutrophils and reduced eosinophil counts. After PAF, FP enhanced transient neutropenia at 5 min and facilitated the recovery of oxygen tension in arterial blood (FP: 93+/-4 mmHg; P: 83+/-4 mmHg) at 45 min, without influencing the increases in Rrs. In conclusion, the improvement of platelet-activated factor-induced oxygen tension in arterial blood disturbances after fluticasone proprionate suggests that inhaled glucocorticosteroids may possess vasoconstrictor properties in the pulmonary circulation.
Deskriptorji		PLATELET ACTIVATING FACTOR PULMONARY GAS EXCHANGE ASTHMA ANDROSTADIENES BRONCHODILATOR AGENTS SEX FACTORS ADULT ADMINISTRATION, INHALATION BLOOD GAS ANALYSIS CROSS-OVER STUDIES DOUBLE-BLIND METHOD DRUG INTERACTIONS PULMONARY VENTILATION TIME FACTORS TREATMENT OUTCOME