Avtor/Urednik		Leivo, Ilmo; Jee, Kowan Ja; Heikinheimo, Kristiina; Laine, Merja; Ollila, Juha; Nagy, Balint; Knuutila, Sakari
Naslov		Gene expression in major types of salivary gland carcinoma
Tip		članek
Vir		In: Vizjak A, Ferluga D, Bussolati G, editors. Update in pathology. Proceedings of the 19th European congress of pathology: nephropathology pre-congress meeting advances in nephrology, pulmonary pathology pre-congress meeting; 2003 Sep 6-11; Ljubljana. Ljubljana: Faculty of medicine,
Leto izdaje		2003
Obseg		str. 157-8
Jezik		eng
Abstrakt		Gene expression profiles were determined in mucoepidermoid carcinoma (MEC), acinic cell carcinoma (ACC), salivary duct carcinoma (SDC), and adenoid cystic carcinoma (AdCC) of salivary gland, using cDNA arrays representing 1176 cancer-related human genes. Findings were validated by quantitative RT-PCR. Only five genes (FNl, TIMPI, BGN, HXB, and IGFBPS) were overexpressed in all carcinoma types, and sixteen genes including MADH4/ SMAD4 and CREBBP were underexpressed in all types. In hierarchical clustering, gene expression profiles were separated into MEC and ACC/SDC groups. In significance analysis of microarrays (SAM), forty-three genes were significantly differently expressed between the groups including IL-6, CASP10, and KRT14. The small number of jointly deregulated cancer-related genes suggests a significant heterogeneity in pathogenetic mechanisms of major types of salivary gland carcinoma. Gene profiles of salivary gland carcinoma and database records on pancreatic carcinoma show similarities in growth control-related gene derangement. Genes selected by SAM might prove useful as tools in differential diagnosis.
Deskriptorji		SALIVARY GLAND NEOPLASMS GENE EXPRESSION POLYMERASE CHAIN REACTION CARCINOMA, MUCOEPIDERMOID CARCINOMA, ACINAR CELL CARCINOMA, ADENOID CYSTIC