Avtor/Urednik		Ružić-Medvešček, N
Naslov		Ehokardiografski parametri funkcije in morfologije levega prekata pri od insulina odvisnih diabetikih (tip I) brez znakov angiopatije
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1991
Obseg		str. 43
Jezik		slo
Abstrakt		A high prevalence of left ventricular (LV) dysfunction in insulin-dependent diabetic patients (type I) has been reported. We investigated systolic and diastolic function as well as morphological characteristics of LV in SO diabetics (31 men, 19 women) and 50 age- and sex-matched healthy control subjects. Diabetic patients (mean age 30.6 + 6.1 yrs, mean duration of disease 7.3 +- 5.1 yrs) had a fairly good metabolic long-term control (mean hemoglobin HbAlc 8.0 +- 1.2 per cent ), no overt clinical heart disease, signs of microvascular complications or autonomic cardiac neuropathy. DeterIninants of LV systolic function as heart rate, systolic pressure and end-systolic LV meridional wall stress, were not significaTitly different. Diabetics had smaller indexes of LV diastolic (p = 0.01) and systolic dinIensions and increased systolic thickeness of LV posterior wall (p = 0.05), whereas LV mass was similar to controls. Cardiac output was insignificantly greater in patients (p = 0.06). Parameters of myocardial contractility EF and FS were slightly but insignificantly increased in patients, whereas MVCF was significantly greater (p less th. 0.05). Isovolumetric relaxation period was significantly longer in patients as well (p less th. 0.007). Some morphological characteristics of LV were in negative correlation with chronic metabolic control and duration of the disease. In conclusion, type I diabetics without microangiopathy or overt clinical heart disease do not differ from healthy control subjects in hemodynamic indices of afterload and heart rate, but they have discret sign of an increased LV systolic function and myocardial contractility, mildly reduced LV with normal LV mass, and prolonged myocardial relaxation, a characteristic pattern of restrictive cardiomyopathy. There is a tendency towards a smaller LV with worse metabolic control and longer duration of the
Deskriptorji		DIABETES MELLITUS, INSULIN-DEPENDENT ECHOCARDIOGRAPHY HEART VENTRICLE SYSTOLE BLOOD PRESSURE HEART RATE MYOCARDIAL CONTRACTION CARDIAC VOLUME DIASTOLE