Avtor/Urednik		Cvelbar, Mirjam
Naslov		Dejavniki tveganja in napovedni dejavniki pri bolnicah z dvojnim primarnim rakom: epitelnim rakom jajčnika in rakom dojke
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2003
Obseg		str. 44
Jezik		slo
Abstrakt		Background: Ovarian cancer is the leading cause of death among gynecologic cancers in Slovenia and worldwide. While adequate screening tests for the general female population are lacking, the detection of early stages of the disease is most successful in high-risk women. The most important known risk factor for ovarian cancer is the BRCAI-2 mutation, which is clinically often manifested through a positive family history of cancer of breast and ovary. Whether in women with a positive family history of cancer of breast and ovary and/or with the BRCAI-2 mutation present some other risk and prognostic factors are important, as in the general population, remains to be elucidated. Recent studies have shown that in double primary cancer of breast and ovary, the BRCAI-2 mutation is present in at least 86-87.5% of cases. Therefore, this group is the most suitable for such an analysis. The aim of this study was to verify the hypothesis that in the group of patients with double primary cancer (epithelial ovarian cancer and breast cancer) some other risk factors in addition to a specific family history of cancer, as well as unfavourable pathomorphological prognostic factors, are more expressed than in the control group of patients with a sporadic epithelial ovarian cancer. Methods: We compared the study group of 31 patients with double primary cancer (ovarian epithelial cancer and breast cancer) to the control group of 62 patients with a single, sporadic epithelial ovarian cancer and negative specific family history. The data were obtained from the Cancer Registry of Slovenia and from clinical records. For every patient we filled-in a protocol and analysed the data comparing other risk factors in addition to the specific family history and prognostic clinica.l and pathomorphological factors. Statistical analysis was performed using descriptive statistics, Chi-square test and t test. (Abstract truncated at 2000 characters).
Deskriptorji		OVARIAN NEOPLASMS BREAST NEOPLASMS NEOPLASMS, SECOND PRIMARY GENES, BRCA1 MEDICAL HISTORY TAKING REGISTRIES RISK FACTORS MENARCHE MENOPAUSE ESTROGEN REPLACEMENT THERAPY AGE FACTORS