Avtor/Urednik		Pavlin, Rudi
Naslov		Kromogranin A in njegova klinična uporabnost
Prevedeni naslov		Cromogranin A and its clinical use
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 72, št. 9
Leto izdaje		2003
Obseg		str. 507-13
Jezik		slo
Abstrakt		Background. An old widely recepted opinion was that the medullary part of the suprarenal gland was primarily responsible for a adequate response to stress. Recently a broader significance of the gland has been recognised. The chromogranin A which is produced and secreted by its enterochromaffine cells is extensively involved in several physiological and pathological processes in the body. Determination of the serum concentration of chromogranin A is nowadays extremely usefulfor diagnosis of the neuroendocrine tumors of the gastrointestinal tract. Conclusions. In the present article its localisation in the body and its biochemistry are described, as well as normal serum concentration values and their changes in various pathological states.
Izvleček		Izhodišča. Staro splošno mnenje je bilo, da je sredica nadobistnice predvsem pomembna za ustrezen odziv na stres. Zdaj spoznavamo njen širši pomen. S kromograninom A, izločkom svojih kromafinih celic, in njegovimi peptidi na široko posega v fiziološka in patološka dogajanja v telesu. Določanje serumske koncentracije kromogranina A je dandanes najbolj v rabi kot pomoč pri diagnosticiranju predvsem nevroendokrinih tumorjev prebavne cevi. Zaključki. V prispevku so opisani: njegova razširjenost v organizmu, biokemija in normalne in patološke vrednosti pri različnih patoloških procesih.
Deskriptorji		CHROMOGRANINS NEUROENDOCRINE TUMORS PHEOCHROMOCYTOMA ADRENAL GLAND NEOPLASMS CARCINOID TUMOR STOMACH NEOPLASMS PROSTATIC NEOPLASMS HYPERTENSION KIDNEY FAILURE