Avtor/Urednik		Trotovšek, Blaž
Naslov		Primarni sklerozantni holangitis
Prevedeni naslov		Primary sclerosing cholangitis
Tip		članek
Vir		In: Jelenc F, editor. Zbornik simpozija Kirurgija žolčnika in žolčevodov; 2003 okt; Ljubljana. Ljubljana: Klinični center, Klinični oddelek za abdominalno kirurgijo,
Leto izdaje		2003
Obseg		str. 116-21
Jezik		slo
Abstrakt		Background. Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease of unknown etiology characterized by diffuse fibrosing inflammation of ihe intrahepatic and extrahepatic bile ducts, leading to obliteration of the biliary tree, biliary cirrhosis and ultimately to liver failure. The most dreaded complication of PSC is cholangiocarcinoma. Diagnosis. The diagnosis of PSC currently relies on clinical history of recurrent fever, pain and jaundice, biochemical profile and on demonstration of pathognomonic cholangiographic findings in a patient after exclusion of secondary causes of sclerosing cholangitis. Treatment. There is no effective medical therapy for primary treatment of PSC, although recent evidence suggests that the combination of ursodeoxycholic acid and immunosuppressive therapy may hold back the disease process. For patients with end-stage PSC, orthotopic liver transplantation (OLT) remains the only curative therapy, although there is clear i evidence that PSC may recur in the liver allograft. Palliative biliary reconstruction has been largely replaced by curative OLT.
Deskriptorji		CHOLANGITIS, SCLEROSING CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE